# Ketosis-Prone Diabetes in Severe Hypertriglyceridemia-Induced Pancreatitis: A Case Report

**Authors:** Abdullah M Almutairi, Sheima M Dahman, Mushabab A Alshahrani, Saleh N Alkurini

PMC · DOI: 10.7759/cureus.93035 · Cureus · 2025-09-23

## TL;DR

This case report describes a rare condition where a woman developed diabetes-related ketoacidosis and pancreatitis due to high triglycerides, highlighting the complex metabolic interactions.

## Contribution

The paper presents a unique clinical case linking ketosis-prone diabetes, severe hypertriglyceridemia, and pancreatitis, emphasizing the need for multidisciplinary care.

## Key findings

- A 41-year-old female presented with ketosis-prone diabetes and severe hypertriglyceridemia-induced pancreatitis.
- The case illustrates the complex interplay between metabolic disturbances and the importance of comprehensive management.
- Multidisciplinary approaches are needed to address underlying causes and prevent complications.

## Abstract

Diabetic ketoacidosis (DKA) is a serious acute complication commonly associated with type 1 diabetes mellitus (T1DM). It is characterized by elevated blood glucose levels, increased ketone production due to insufficient insulin, and metabolic acidosis. Acute pancreatitis (AP) is an inflammatory condition of the pancreas that can range from mild, self-limiting episodes to severe, life-threatening illness. The triad of DKA, hypertriglyceridemia, and AP presents a unique and challenging clinical scenario. This report describes the case of a 41-year-old female diagnosed with ketosis-prone diabetes and severe hypertriglyceridemia-induced pancreatitis. The case highlights several important considerations for clinicians and underscores the intricate interplay between metabolic disturbances, emphasizing the need for a comprehensive, multidisciplinary approach to management and treatment to address underlying causes and prevent future complications.

## Linked entities

- **Diseases:** diabetic ketoacidosis (MONDO:0012819), type 1 diabetes mellitus (MONDO:0005147), acute pancreatitis (MONDO:0006515)

## Full-text entities

- **Genes:** INS (insulin) [NCBI Gene 3630] {aka IDDM, IDDM1, IDDM2, ILPR, IRDN, MODY10}
- **Diseases:** pancreas (MESH:D010190), metabolic (MESH:D008659), AP (MESH:D010195), inflammatory condition (MESH:D007249), DKA (MESH:D016883), Ketosis-Prone Diabetes (MESH:D003922), Hypertriglyceridemia (MESH:D015228), metabolic acidosis (MESH:D000138)
- **Chemicals:** blood glucose (MESH:D001786), ketone (MESH:D007659)

## Full text

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## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12548971/full.md

## References

30 references — full list in the complete paper: https://tomesphere.com/paper/PMC12548971/full.md

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Source: https://tomesphere.com/paper/PMC12548971