# Microbial links to Alzheimer’s disease

## TL;DR

This paper reviews how microbes might be linked to Alzheimer's disease, suggesting they could trigger or worsen the condition.

## Contribution

The paper provides an updated review on the potential role of infectious pathogens in Alzheimer’s disease progression.

## Key findings

- There are notable correlations between microbes and Alzheimer’s disease pathologies.
- Pathogens may trigger or exacerbate Alzheimer’s disease, even if they are not the direct cause.
- The role of infections in AD pathogenesis remains an important area for further research.

## Abstract

Alzheimer’s disease (AD) is a common chronic neurodegenerative disease that is characterized by (1) plaques, (2) neuronal death, (3) hyperphosphorylation of tau proteins, and (4) memory deficits. Despite extensive research, the underlying cause of AD is not fully understood. Evidence that infectious pathogens may trigger AD has been documented for decades. There are notable correlations between microbes (including bacteria, viruses, and fungi) and AD pathologies. Although it is yet to be determined if pathogenic microbes are the causative agent or a contributing factor to AD, the role of infections in the pathogenesis of AD should not be ignored. Even though the pathogens may not cause AD, they may play a direct role in the triggering or exacerbation of AD progression. In this mini review, the current status of pathogens’ role in AD etiology will be presented.