Engineering Two-in-One Nanoparticles for Simultaneous Delivery of Graphene Quantum Dot and Pemetrexed
Umut Can Öz, Berrin Küçüktürkmen, I. Jénnifer Gómez, Amr Elsherbeny, Seda Ipek Tekneci, Özgür Eşim, Selin Göksever, Umut Uğur Özköse, Sevgi Gülyüz, Claudia Bazán-Cobelo, Özgür Yılmaz, Aylin Üstündağ, Jiřina Medalová, Asuman Bozkır, Lenka Zajíčková, Engin Er
TL;DR
This paper introduces a new nanoparticle system that delivers both a chemotherapy drug and fluorescent imaging probes for better cancer treatment and monitoring.
Contribution
A novel multifunctional nanocarrier system for simultaneous drug delivery and bioimaging in cancer treatment is developed.
Findings
The optimized nanoparticles showed high drug and quantum dot encapsulation efficiency.
Nanoparticle-loaded pemetrexed significantly enhanced cytotoxicity against MCF-7 cells.
Confocal microscopy confirmed efficient intracellular uptake and strong fluorescence signals.
Abstract
The simultaneous delivery of therapeutic agents and imaging probes using polymeric nanoparticles (NPs) has gained significant attention for cancer treatment. In this work, we developed a multifunctional nanocarrier system composed of an amphiphilic block copolymer, poly(2-ethyl-2-oxazoline)-b-poly(ε-caprolactone) (PEtOx-b-PCL), and dimethyldidodecylammonium bromide (DDAB), for the codelivery of the chemotherapeutic drug pemetrexed (PMT) and nitrogen- or sulfur-doped graphene quantum dots (N-GQDs or S-GQDs) as fluorescent probes. Critical formulation parameters were optimized using a central composite design (CCD). The optimized NPs exhibited favorable physicochemical properties, including positive surface charge (6–8 mV), hydrodynamic diameters of ∼140 nm, and high encapsulation efficiency for both PMT (46–56%) and GQDs (>98%). In vitro assays revealed that PMT-loaded nanoparticles…
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Taxonomy
TopicsCarbon and Quantum Dots Applications · Graphene and Nanomaterials Applications · Nanocluster Synthesis and Applications