Lanostane–Meroterpene Conjugates with Unusual Aryl Ether Linkage and a Lanostane Dimer from Artificially Cultivated Fruiting Bodies of Ganoderma cf. hochiminhense

TL;DR

Scientists discovered ten new compounds from a cultivated mushroom, some of which show cytotoxic effects on cancer and non-cancer cells.

Contribution

The discovery of ten new compounds, including unique lanostane–meroterpene conjugates and a lanostane dimer, from a cultivated mushroom species.

Findings

Ganohochimins A–H and ganohochimate A have unique structures confirmed through chemical cleavage methods.

Ganohochimins showed cytotoxic activity against small-cell lung cancer and Vero cells with IC50 values ranging from 6.3 to 33 μM.

Abstract

Ten previously undescribed compounds, including eight
lanostane–meroterpene
conjugates, ganohochimins A–H (1–8), a lanostane dimer, ganohochimate A (9), and
a meroterpenoid, fornicin F (10), were isolated from
the cultivated mushroom Ganoderma cf. hochiminhense­(strain TBRC-BCC 22084). The 24S-configuration of
ganohochimin A (1) was determined by cleavage of the
aryl ether under acidic conditions. The structure of ganohochimate
A (9) was confirmed by alkaline hydrolysis to cleave
into two lanostane units. Ganohochimins exhibited cytotoxicity against
NCI-H187 (small-cell lung cancer) cells (IC50 7.7–33
μM) and noncancerous Vero cells (IC50 6.3–30
μM).

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