Isoconversional Kinetic Analysis and ANN-Based Prediction of Metformin Pyrolysis for Sustainable Waste Management
Ramesh Potnuri, Maheswata Lenka, Chinta Sankar Rao, Harshini Dasari
TL;DR
This study explores pyrolysis as a sustainable method to manage pharmaceutical waste by recovering valuable compounds from metformin.
Contribution
The study introduces an ANN-based prediction model for metformin pyrolysis and evaluates its potential for pharmaceutical waste valorization.
Findings
Pyrolysis of metformin produced liquid-phase products containing the active pharmaceutical ingredient and other compounds.
An ANN model accurately predicted mass loss during pyrolysis using temperature and heating rate as inputs.
Recovered APIs and byproducts could be reused for energy or chemical synthesis, supporting circular economy goals.
Abstract
Pharmaceutical waste poses a growing environmental concern due to its persistence and potential ecological impacts, necessitating effective and sustainable management strategies. This study investigates the pyrolysis of metformin as a means to valorize pharmaceutical waste within a circular economy framework. Pyrolysis experiments conducted on 500 mg of metformin demonstrated the formation of liquid-phase products, characterized by GC–MS, which revealed a high concentration of the active pharmaceutical ingredient (API) alongside carbonaceous, nitro, and acidic compounds. Comprehensive thermogravimetric analyses at heating rates of 10, 20, 30, and 40 °C/min were performed to evaluate the thermal decomposition behavior. Kinetic parameters were determined using four isoconversional methods, namely KAS, FWO, Starink, and FRD, yielding average activation energies of 101.4, 105.8, 101.4, and…
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Taxonomy
TopicsThermal and Kinetic Analysis · Thermochemical Biomass Conversion Processes · Chemistry and Chemical Engineering