# Editorial: Spotlight on aging: role of exercise and nutrition in healthy longevity

**Authors:** Antonio Paoli, Richard Siow, Tatiana Moro

PMC · DOI: 10.3389/fragi.2025.1698219 · 2025-10-09

## Full-text entities

- **Genes:** PPARGC1A (PPARG coactivator 1 alpha) [NCBI Gene 10891] {aka LEM6, PGC-1(alpha), PGC-1alpha, PGC-1v, PGC1, PGC1A}, MTOR (mechanistic target of rapamycin kinase) [NCBI Gene 2475] {aka FRAP, FRAP1, FRAP2, RAFT1, RAPT1, SKS}
- **Diseases:** muscle loss (MESH:D009135), depressive mood (MESH:D003866), chronic disease (MESH:D002908), frailty (MESH:D000073496), pain (MESH:D010146), mobility (MESH:D014086), sarcopenia (MESH:D055948), inflammation (MESH:D007249), knee osteoarthritis (MESH:D020370), Alzheimer's (MESH:D000544)
- **Chemicals:** chain fatty acid (-)
- **Species:** gut metagenome (species) [taxon 749906], Faecalibacterium prausnitzii (species) [taxon 853], Homo sapiens (human, species) [taxon 9606]

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Source: https://tomesphere.com/paper/PMC12547513