# Lyme Endocarditis: A Case Report

**Authors:** Mayyadah H Alabdely, Patricia Bartley, Carmela D Tan, Hannah Wang, Nabin K Shrestha

PMC · DOI: 10.1093/ofid/ofaf623 · 2025-10-06

## TL;DR

A 67-year-old woman developed heart valve issues after Lyme disease treatment, and spirochetes were found in her valve tissue, marking the first confirmed case of Lyme endocarditis.

## Contribution

This is the first documented case of Lyme endocarditis confirmed by visualizing spirochetes in cardiac valve tissue.

## Key findings

- Spirochetes were identified in valve tissue using Warthin-Starry stain.
- Molecular testing confirmed the presence of Borrelia spp. DNA in the tissue.
- The case highlights a rare complication of Lyme disease affecting the heart.

## Abstract

A 67-year-old woman from Pennsylvania underwent mitral valve repair for regurgitation that developed shortly after Lyme disease treatment. Warthin-Starry stain revealed spirochetes in valve tissue and molecular testing found DNA of Borrelia spp. We report the first Lyme endocarditis case supported by visualization of spirochetes in cardiac valve tissue.

## Linked entities

- **Diseases:** Lyme disease (MONDO:0019632)

## Full-text entities

- **Diseases:** Lyme Endocarditis (MESH:D004696), Lyme disease (MESH:D008193)
- **Chemicals:** Warthin-Starry (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12547496/full.md

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Source: https://tomesphere.com/paper/PMC12547496