# Third-Trimester HIV Viremia Treated With Long-Acting Cabotegravir and Rilpivirine: A Case Report

## TL;DR

A pregnant individual experienced a rapid drop in HIV levels using long-acting injectable drugs during the third trimester.

## Contribution

This is the first case to show significant HIV viral load reduction using long-acting injectables during pregnancy.

## Key findings

- Long-acting cabotegravir and rilpivirine reduced HIV viral load rapidly in the third trimester.
- The case highlights challenges with daily oral HIV therapy during pregnancy.

## Abstract

We report the first case to quantitatively demonstrate a rapid and substantial viral load reduction using long-acting cabotegravir and rilpivirine in the third trimester of pregnancy. This case underscores the challenges some pregnant individuals face with daily oral antiretroviral therapy and the potential role of long-acting injectables in select scenarios.