# Dataset from a randomized controlled trial comparing intensive short-term dynamic psychotherapy to waitlist for treatment-resistant depression

**Authors:** Rasoul Heshmati, Frederik J. Wienicke, Ellen Driessen

PMC · DOI: 10.1016/j.dib.2025.112126 · 2025-10-07

## TL;DR

This study provides data from a trial comparing a short-term therapy to a waitlist for people with depression that did not respond to medication.

## Contribution

The dataset offers longitudinal outcomes from a randomized controlled trial on ISTDP for treatment-resistant depression.

## Key findings

- The dataset includes demographic and psychological measures from 86 participants with treatment-resistant depression.
- Outcome measures were collected at baseline, post-treatment, and 3-month follow-up.
- The study compares ISTDP to a waitlist condition using standardized psychological scales.

## Abstract

The data presented in this article concern 86 Iranian individuals with treatment-resistant depression (TRD), who participated in a randomized controlled trial comparing intensive short-term dynamic psychotherapy (ISTDP) to a waitlist condition. Adults with major depressive disorder (MDD), who had not responded to prior treatment with antidepressant medication, were randomly assigned to ISTDP (n = 43) or waitlist (n = 43). The dataset includes demographic variables and the outcome measures: all subscales of the Weinberger Adjustment Inventory (WAI), and the Negative Affect subscale from the Positive and Negative Affect Schedule (PANAS-NA). Outcome measures were collected at baseline, post-treatment (10 weeks), and 3-month follow-up.

## Linked entities

- **Diseases:** major depressive disorder (MONDO:0002009)

## Full-text entities

- **Diseases:** TRD (MESH:D061218), MDD (MESH:D003865)

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Source: https://tomesphere.com/paper/PMC12547156