Novel heat exchanger in extracorporeal circuit: technical and biological feasibility
Jiri Ruzicka, Filip Tichanek, Jiri Skorpil, Jiri Dejmek, Lukas Bolek, Ondrej Brzon, Richard Palek, Jachym Rosendorf, Vladimira Moulisova, Maria Stefania Massaro, Václav Liska, Jitka Kuncova
TL;DR
A new device that cools blood in an extracorporeal circuit is technically feasible and safe in pigs, with no harmful effects on blood cells or organ function.
Contribution
A novel heat exchanger for extracorporeal circuits is introduced, demonstrating technical and biological feasibility in a porcine model.
Findings
The device successfully maintained temperature and pressure differentials without circuit issues.
No adverse effects on erythrocyte stability or organ function were observed.
Local hypothermia may reduce surgery-induced inflammation.
Abstract
To evaluate a novel anticoagulation strategy in an extracorporeal circuit, we introduce a device that induces local hypothermia as blood flows through the circuit. Using a pig model, we assessed its technical feasibility, biocompatibility, and safety. Sixteen pigs were randomly assigned to either the cooled group or the control group and underwent midline laparotomy to establish extracorporeal circulation (blood flow 500 ml/min) via the caudal vena cava for up to four hours. Blood samples were collected at baseline and at 15, 60, and 240 min during the experiment. In the cooled group, blood was cooled to 20 °C and then rewarmed to 37 °C, while in the control group, blood was maintained at 37 °C. A total of 6 cooled and 4 control pigs completed 4 h of the experiment. Our findings confirm the technical feasibility of the proposed device, which effectively maintained the required…
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Taxonomy
TopicsThermal Regulation in Medicine · Mechanical Circulatory Support Devices · Respiratory Support and Mechanisms