# Editorial: Application of next-generation sequencing in clinical settings

**Authors:** Zhi Chai, Han Mei, Quan Li, Iram Maqsood, Jingxian Cai, Marilyn M. Li, Feng Xu, Xiaonan Zhao

PMC · DOI: 10.3389/fgene.2025.1700975 · 2025-10-09

## Full-text entities

- **Genes:** PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) [NCBI Gene 5290] {aka CCM4, CLAPO, CLOVE, CWS5, HMH, MCAP}, SLC5A6 (solute carrier family 5 member 6) [NCBI Gene 8884] {aka COMNB, NERIB, SMVT, SMVTD, hSMVT}, KCNH2 (potassium voltage-gated channel subfamily H member 2) [NCBI Gene 3757] {aka ERG-1, ERG1, H-ERG, HERG, HERG1, Kv11.1}
- **Diseases:** opacities (MESH:D003318), genetic disorders (MESH:D030342), Long QT Syndrome type 2 (MESH:D008133), SMVT deficiency (MESH:D007153), IHPRF1 syndrome (OMIM:615419), mitochondrial disease (MESH:D028361), syndromes (MESH:D013577), mucopolysaccharidosis (MESH:D008059), metastases (MESH:D009362), tumor (MESH:D009369)
- **Chemicals:** osimertinib (MESH:C000596361)
- **Species:** Homo sapiens (human, species) [taxon 9606]

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Source: https://tomesphere.com/paper/PMC12545442