# Giant spontaneous epidermal cyst of the labia minora: a rare case report and literature review

**Authors:** Xiang Li, Yuanyuan Bai, Jie Li, Ruili Li, Jinying Fu

PMC · DOI: 10.3389/fonc.2025.1695646 · 2025-10-09

## TL;DR

A rare case of a large epidermal cyst in the labia minora was successfully treated with surgery, highlighting the need for prompt removal to avoid complications.

## Contribution

Reports a rare case of a giant spontaneous epidermal cyst in the labia minora with concurrent endometriosis and a Bartholin’s cyst.

## Key findings

- The patient had an epidermal cyst larger than 8 cm in the labia minora, a very rare occurrence.
- Surgical excision resolved symptoms and confirmed the diagnosis of epidermal cyst and endometriosis.
- No recurrence or complications were observed during 3 months of follow-up.

## Abstract

Epidermal cysts are benign subcutaneous masses resulting from the implantation of epithelial cells, following trauma or surgery. Giant spontaneous epidermal cysts of the labia minora are rare. To date, only 3 cases of epidermal cysts located in the labia minora have been reported worldwide.

This study presents a case involving an epidermal cyst of the labia minora with a diameter exceeding 8 cm, accompanied by endometriosis within an episiotomy scar and a concurrent Bartholins’s cyst. All lesions were surgically excised, successfully resolving the patient’s symptoms, and the final pathological diagnosis confirmed an epidermal cyst and endometriosis. The patient recovered well postoperatively, and follow-up at 3 months revealed no discomfort or complications.

This case shows that spontaneous epidermal cysts of the labia minora are very rare and can enlarge rapidly over a short period. Prompt and thorough surgical excision is recommended to prevent recurrence and the potential for malignant transformation.

## Linked entities

- **Diseases:** endometriosis (MONDO:0005133)

## Full-text entities

- **Diseases:** Bartholins's cyst (MESH:D003560), endometriosis (MESH:D004715), trauma (MESH:D014947), Epidermal cysts (MESH:D004814)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12545134/full.md

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Source: https://tomesphere.com/paper/PMC12545134