# Mycoplasma pneumoniae‐Associated Mucositis: A Diagnostic Dilemma

**Authors:** Mahesh Mathur, Sumit Paudel, Nabita Bhattarai, Sambidha Karki, Shilpa Maharjan, Sandhya Regmi

PMC · DOI: 10.1002/ccr3.71338 · Clinical Case Reports · 2025-10-22

## TL;DR

This paper discusses a rare condition called Fuchs syndrome linked to Mycoplasma pneumoniae infection, highlighting the importance of early diagnosis and antibiotic treatment to avoid complications.

## Contribution

The novelty lies in reporting a case where Fuchs syndrome improved with oral antibiotics, suggesting a potential treatment approach.

## Key findings

- Fuchs syndrome can be associated with Mycoplasma pneumoniae infection.
- Treatment with oral antibiotics led to significant improvement in the reported case.
- Early suspicion of Mycoplasma can prevent diagnostic delays and adverse outcomes.

## Abstract

Fuchs syndrome is a mucosal variant of Stevens‐Johnson syndrome (SJS) without cutaneous lesions, mostly affecting the mucosa of the mouth, conjunctiva, and genitalia, that occurs in a background of 
Mycoplasma pneumoniae
 and herpes simplex infection. Treatment with antibiotics such as macrolides, tetracycline, or fluoroquinolones has been shown to limit the pulmonary disease, but it is unclear whether the incidence or severity of the mucocutaneous eruption is reduced. In the absence of cutaneous manifestations, the patient often seeks multiple specialists, including ophthalmologists, dentists, otolaryngologists, gynecologists, or urologists, so a suspicion of Mycoplasma in such cases can avoid delay in diagnosis and adverse sequelae. We hereby report a case of 
Mycoplasma pneumoniae
‐associated Fuchs syndrome which showed significant improvement with oral antibiotics.

## Linked entities

- **Diseases:** Stevens-Johnson syndrome (MONDO:0018229)

## Full-text entities

- **Diseases:** cutaneous lesions (MESH:D009059), mucocutaneous eruption (MESH:D003875), Fuchs syndrome (MESH:D005642), Mucositis (MESH:D052016), pulmonary disease (MESH:D008171), herpes simplex infection (MESH:D006561), SJS (MESH:D013262)
- **Chemicals:** macrolides (MESH:D018942), fluoroquinolones (MESH:D024841), tetracycline (MESH:D013752)
- **Species:** Homo sapiens (human, species) [taxon 9606], Mycoplasmoides pneumoniae (Filterable agent of primary atypical pneumonia, species) [taxon 2104]

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12544704/full.md

## References

11 references — full list in the complete paper: https://tomesphere.com/paper/PMC12544704/full.md

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Source: https://tomesphere.com/paper/PMC12544704