# Indirect associations of pain resilience and kinesiophobia with the relationship between physical activity and chronic pain

**Authors:** Nils Georg Niederstrasser, Nina Attridge, P. Maxwell Slepian, Cid André Fidelis de Paula Gomes, Cid André Fidelis de Paula Gomes, Aynollah Naderi, Aynollah Naderi, Aynollah Naderi

PMC · DOI: 10.1371/journal.pone.0334144 · PLOS One · 2025-10-22

## TL;DR

Some people stay active despite chronic pain, possibly due to high pain resilience and low fear of movement.

## Contribution

The study identifies pain resilience as a key psychological factor in maintaining physical activity despite chronic pain.

## Key findings

- Pain resilience significantly mediates the relationship between chronic pain and physical activity.
- Kinesiophobia's indirect effect on physical activity is not significant when pain resilience is considered.
- Higher pain resilience and male gender are associated with increased physical activity levels.

## Abstract

Pain is associated with a decrease in physical activity for most individuals. Nevertheless, some individuals manage to maintain physical activity levels despite pain. While the exact psychological mechanisms behind this are unknown, it may possibly be due to low kinesiophobia and high pain resilience levels. This study aimed to examine the direct and indirect associations of pain resilience and kinesiophobia with the relationship between pain and physical activity.

In this cross-sectional study data were collected from 172 participants suffering from chronic pain. Three path models were fitted to assess the indirect associations between pain resilience and kinesiophobia in the relationship between physical activity and musculoskeletal pain individually and simultaneously. Additionally, a linear regression model was fitted to examine the impact of psychological predictors of physical activity while accounting for musculoskeletal pain.

Significant proportions of the association between musculoskeletal pain on physical activity occurred through both pain resilience and kinesiophobia. Nevertheless, when examined simultaneously, only the indirect associations via pain resilience remained significant. Similarly, when predicting physical activity levels, only high levels of pain resilience and male gender were associated with increased physical activity levels, whereas kinesiophobia was not.

This highlights the central role pain resilience plays in retaining physical activity levels when faced with chronic pain. It also implies that pain resilience predicts physical activity levels beyond pain intensity, kinesiophobia, pain duration, and pain spread. It is, therefore, imperative to examine avenues of increasing pain resilience among individuals suffering from chronic pain, not only to improve their pain, but also their overall health and well-being. This possibly bears implications for clinical practice and may inform treatment approaches, whereby pain resilience may be boosted to increase physical activity levels. Nevertheless, given the cross-sectional design, longitudinal and experimental studies are needed to confirm the causal pathways.

## Full-text entities

- **Diseases:** chronic pain (MESH:D059350), Pain (MESH:D010146), musculoskeletal pain (MESH:D059352)

## Full text

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## Figures

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## References

47 references — full list in the complete paper: https://tomesphere.com/paper/PMC12543166/full.md

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Source: https://tomesphere.com/paper/PMC12543166