# A Case Report and Global Perspective on Fusarium Superficial Keratitis in the Pediatric Population

**Authors:** S Avinash, Rajesh Kanna Kannabiran, Rahul Garg, Pravalika Rebbala, Sree Ranjani S, Siddharam S Janti, Shalam Nikhat Sheerin, Rahul Narang

PMC · DOI: 10.7759/cureus.92937 · Cureus · 2025-09-22

## TL;DR

A 9-year-old boy developed Fusarium keratitis after eye trauma and steroid use, successfully treated with antifungal drugs.

## Contribution

Highlights the importance of rapid diagnosis and treatment in pediatric Fusarium keratitis cases.

## Key findings

- Fusarium solani was identified using mass spectrometry in a pediatric keratitis case.
- Topical natamycin and voriconazole healed the infection without surgery.
- Unsupervised corticosteroid use increases risk in endemic regions.

## Abstract

Fungal keratitis is a major cause of corneal blindness in tropical regions, with Fusarium species predominating. Pediatric cases, though less common, carry a greater risk of amblyopia and long-term disability. We report a nine-year-old boy who developed Fusarium keratitis after minor ocular trauma and unsupervised corticosteroid use. Corneal scrapings showed septate hyphae, and identification confirmed Fusarium solani by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Treatment with topical natamycin and voriconazole led to complete healing without surgery. This case highlights the need for early recognition, rapid microbiological confirmation, and appropriate antifungal therapy in pediatric fungal keratitis, while underscoring the dangers of unsupervised corticosteroid use in endemic regions.

## Linked entities

- **Chemicals:** natamycin (PubChem CID 5284447), voriconazole (PubChem CID 71616)
- **Diseases:** amblyopia (MONDO:0001020)
- **Species:** Fusarium solani (taxon 169388)

## Full-text entities

- **Diseases:** Fusarium keratitis (MESH:D060585), amblyopia (MESH:D000550), corneal blindness (MESH:D003316), Fungal keratitis (MESH:D009181), ocular trauma (MESH:D014947), Keratitis (MESH:D007634)
- **Chemicals:** natamycin (MESH:D010866), voriconazole (MESH:D065819)
- **Species:** Fusarium solani (species) [taxon 169388]

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12543011/full.md

## References

19 references — full list in the complete paper: https://tomesphere.com/paper/PMC12543011/full.md

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Source: https://tomesphere.com/paper/PMC12543011