# Integrating kidney function assessment into the clinical interpretation of plasma Alzheimer's disease biomarkers

## TL;DR

This paper explores how kidney function affects plasma Alzheimer's disease biomarkers and suggests including kidney health in diagnostic models to improve accuracy.

## Contribution

The study highlights the impact of kidney function on biomarker accuracy and proposes integrating renal indices into Alzheimer's diagnostics.

## Key findings

- Kidney function can alter plasma biomarker levels, affecting diagnostic accuracy.
- Including eGFR in diagnostic models may improve interpretation in older adults with CKD.

## Abstract

As plasma biomarkers like p-tau217 move towards clinical use in Alzheimer's disease (AD), it is important to understand how kidney function may influence their accuracy. Even mild chronic kidney disease (CKD) can alter biomarker levels, potentially impacting test performance. While accounting for renal function may improve specificity, it could reduce sensitivity without greatly changing overall diagnostic accuracy. Most studies focus on mild CKD, leaving gaps in understanding severe CKD—especially in real-world settings like primary care. Including renal indices such as eGFR in diagnostic models could help improve interpretation and minimize misclassification in older adults, where CKD is common.