# Causal-aware reliability assessment of single-channel EEG for transformer-based sleep staging

**Authors:** Yongkang Hu, Xiangbo Yang, Yunhan Xu, Jingpeng Sun

PMC · DOI: 10.3389/fnins.2025.1670124 · Frontiers in Neuroscience · 2025-10-08

## TL;DR

This paper assesses the reliability of single-channel EEG for sleep staging using a Transformer model and finds that central brain region electrodes provide better results.

## Contribution

The study introduces a Transformer-based model and provides causal insights into EEG channel selection for reliable sleep staging.

## Key findings

- Central brain region EEG electrodes show higher accuracy and consistency in sleep staging.
- Transformer-based models improve reliability assessment of single-channel EEG.
- Findings support robust wearable sleep monitoring system design.

## Abstract

Single-channel EEG-based sleep staging methods are well-suited for wearable applications in home environments, offering a practical solution to reduce the diagnostic burden on clinical institutions and address the growing demand for large-scale sleep monitoring. However, its reliability remains a critical concern compared to multi-channel polysomnography (PSG) used in clinical settings. To address this, we propose a Transformer-based sleep staging model and conduct a systematic investigation into the causal-inspired analysis between EEG channel selection and staging reliability. Our experiments reveal that electrodes positioned over the central brain region yield significantly higher accuracy, macro-F1, and consistency in sleep stage classification compared to those located in frontal or occipital regions. These findings provide causal insights into the spatial determinants of perceptual reliability in EEG-based sleep monitoring, supporting the design of robust wearable systems.

## Full-text entities

- **Genes:** FEN1 (flap structure-specific endonuclease 1) [NCBI Gene 2237] {aka FEN-1, MF1, RAD2}
- **Diseases:** sleep disorders (MESH:D012893)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12540495/full.md

## References

21 references — full list in the complete paper: https://tomesphere.com/paper/PMC12540495/full.md

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Source: https://tomesphere.com/paper/PMC12540495