# Association between periodontal disease and prostate disease: a mini review

**Authors:** Shuxin Li, Hongliang Cao, Yueqiu Zhang, Tong Yang, Mingxuan Li, Chensen Lv, Xin Lian

PMC · DOI: 10.3389/fcimb.2025.1669490 · Frontiers in Cellular and Infection Microbiology · 2025-10-08

## TL;DR

This review explores how periodontal disease in the mouth might be linked to prostate diseases like cancer and inflammation.

## Contribution

The paper systematically reviews the emerging connections between oral and prostate health, focusing on potential mechanisms and treatment approaches.

## Key findings

- Periodontal disease is linked to systemic conditions, including prostate diseases.
- Managing periodontal disease may offer new prevention and treatment strategies for prostate conditions.
- The review highlights possible pathological mechanisms connecting oral and prostate health.

## Abstract

Periodontal disease (PD) is one of the most common chronic diseases in the oral cavity, typically referring to chronic inflammation caused by infection with pathogenic microorganisms in the oral cavity. PD primarily affects the tissues surrounding the teeth, leading to inflammation of the gums and periodontal tissues, destruction of the alveolar bone, and even loosening of the teeth. Numerous studies have shown that PD is not limited to the oral cavity but is also associated with the occurrence of diseases in multiple systems throughout the body. In recent years, increasing attention has been directed toward the interaction between PD and prostate diseases. This article reviews the potential associations between PD and prostate conditions such as chronic prostatitis, benign prostatic hyperplasia (BPH), and prostate cancer (PCa). It explores the pathological mechanisms underlying this interaction and its clinical implications. Additionally, this article aims to identify potential pathogenic mechanisms and propose possible approaches for preventing and treating prostate diseases through the management of PD.

## Linked entities

- **Diseases:** periodontal disease (MONDO:0002635), chronic prostatitis (MONDO:0022103), benign prostatic hyperplasia (MONDO:0010811), prostate cancer (MONDO:0005159)

## Full-text entities

- **Diseases:** infection (MESH:D007239), prostate disease (MESH:D011469), BPH (MESH:D011470), chronic prostatitis (MESH:D011472), PD (MESH:D010510), chronic inflammation (MESH:D007249), PCa (MESH:D011471), loosening (MESH:D011475)

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12540478/full.md

## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12540478/full.md

## References

65 references — full list in the complete paper: https://tomesphere.com/paper/PMC12540478/full.md

---
Source: https://tomesphere.com/paper/PMC12540478