# Transcatheter Mitral Valve Replacement With LAMPOON

**Authors:** Julien Feghaly, Naji Maaliki, Yixin Zhang, Mohamed Abdul Qader, Daniel Soffer, Ali Zgheib, Thomas Zeyl, Erol Belli, Valentin Suma, Calvin Choi

PMC · DOI: 10.1016/j.jaccas.2025.105284 · JACC Case Reports · 2025-10-01

## TL;DR

A new technique called LAMPOON prevents dangerous heart complications during a specific valve replacement procedure.

## Contribution

The LAMPOON technique is introduced as a preventive strategy for left ventricular outflow tract obstruction in high-risk TMVR cases.

## Key findings

- All patients underwent successful anterior mitral leaflet laceration with no significant LVOT obstruction.
- Antegrade and tip-to-base LAMPOON techniques are safe and effective for high-risk TMVR patients.

## Abstract

Left ventricular outflow tract (LVOT) obstruction is a potentially fatal complication of transcatheter mitral valve replacement (TMVR), particularly in patients with anatomically high-risk features. LAMPOON (laceration of the anterior mitral leaflet to prevent outflow obstruction) is a transcatheter electrosurgical technique developed to mitigate this risk by modifying anterior mitral leaflet anatomy prior to valve deployment.

We describe our institutional experience with LAMPOON as a preventive strategy in TMVR cases with a high predicted risk for neo-LVOT obstruction.

This case series includes patients with high-risk anatomical features who underwent TMVR with LAMPOON. Variations of the LAMPOON technique, including antegrade and tip-to-base approaches using the “flying-V” electrosurgical wire configuration, were employed based on individual anatomy.

All patients underwent successful anterior mitral leaflet laceration, with no significant LVOT obstruction. Antegrade and tip-to-base LAMPOON techniques are safe and effective adjuncts to TMVR in patients at high risk of LVOT obstruction.

## Full-text entities

- **Diseases:** laceration (MESH:D022125), mitral leaflet (MESH:D008946), outflow obstruction (MESH:D014694), LVOT obstruction (MESH:D000092242)
- **Chemicals:** LAMPOON (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

5 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12540458/full.md

## References

7 references — full list in the complete paper: https://tomesphere.com/paper/PMC12540458/full.md

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Source: https://tomesphere.com/paper/PMC12540458