# Refractory Hypothyroidism: Unexpected Outcome During Treatment of Giant Cell Arteritis

**Authors:** Elise Deprince, Solange Grunenwald, Celine Mouly, Julie Benoit, Philippe J. Caron

PMC · DOI: 10.1002/ccr3.71289 · Clinical Case Reports · 2025-10-21

## TL;DR

This paper discusses a rare case where a patient with giant cell arteritis did not respond well to levothyroxine treatment for hypothyroidism.

## Contribution

The study highlights the challenge of managing refractory hypothyroidism in the context of giant cell arteritis.

## Key findings

- The patient's TSH levels remained abnormal despite levothyroxine treatment.
- Long-term follow-up showed persistent difficulty in restoring normal thyroid function.
- This case emphasizes the need for careful management in such complex patients.

## Abstract

Refractory hypothyroidism is not uncommon in patients treated with oral levothyroxine, and it represents a challenge for clinicians as regards a physiopathological diagnosis and the most appropriate long‐term therapeutic management in order to restore normal TSH concentrations.

Refractory hypothyroidism in a patient with giant cell arteritis: doses of levothyroxine and serum TSH levels during long term follow‐up.

## Linked entities

- **Chemicals:** levothyroxine (PubChem CID 5819)
- **Diseases:** hypothyroidism (MONDO:0005420), giant cell arteritis (MONDO:0008538)

## Full-text entities

- **Diseases:** Giant Cell Arteritis (MESH:D013700), Hypothyroidism (MESH:D007037)
- **Chemicals:** levothyroxine (MESH:D013974)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12540197/full.md

## References

17 references — full list in the complete paper: https://tomesphere.com/paper/PMC12540197/full.md

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Source: https://tomesphere.com/paper/PMC12540197