# Anti-angiogenesis in human lymphomas. New insights

**Authors:** Domenico Ribatti, Roberto Tamma, Giuseppe Ingravallo, Giorgina Specchia

PMC · DOI: 10.3389/fonc.2025.1636332 · Frontiers in Oncology · 2025-10-08

## TL;DR

This paper reviews recent developments in using anti-angiogenic treatments for human lymphomas and suggests combining therapies to improve effectiveness.

## Contribution

The paper highlights new therapeutic strategies to overcome resistance in anti-angiogenic treatment of lymphomas.

## Key findings

- Anti-angiogenic monotherapy alone may not be effective for treating lymphomas.
- Combining anti-angiogenic agents with other treatments could enhance therapeutic outcomes.
- Alternative strategies are needed to address resistance in anti-angiogenic therapy.

## Abstract

Targeting tumor angiogenesis is an advancement in the treatment of hematological malignancies. This article summarizes the most recent advancements in the use of anti-angiogenic agents in the treatment of human lymphomas. Preclinical and clinical studies have evidenced that treating lymphomas with anti-angiogenic monotherapy may not be successful. Alternative therapeutic strategies may be used to overcome resistance to anti-angiogenic therapy, including the association of different anti-angiogenic molecules or their combination with other treatment regimens.

## Full-text entities

- **Diseases:** lymphomas (MESH:D008223), hematological malignancies (MESH:D019337), tumor (MESH:D009369)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## References

57 references — full list in the complete paper: https://tomesphere.com/paper/PMC12540129/full.md

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Source: https://tomesphere.com/paper/PMC12540129