# Incidental intraoperative discovery of a Wolffian tumor in a postmenopausal woman: a case report and literature review

**Authors:** Dong-mei Li, Ming-rong Xi, Xi Zeng

PMC · DOI: 10.3389/fonc.2025.1674008 · Frontiers in Oncology · 2025-10-08

## TL;DR

A rare Wolffian tumor was found in a 54-year-old woman during surgery, highlighting the challenges in diagnosing and treating this uncommon gynecological condition.

## Contribution

This case report adds to the limited literature on FATWO and emphasizes the need for further research on treatment strategies for younger patients.

## Key findings

- FATWO was incidentally discovered in a postmenopausal woman during a routine examination.
- Surgical removal with no adjuvant therapy showed no disease progression after one year.
- Treatment strategies for FATWO in reproductive-age patients remain under-researched.

## Abstract

Female adnexal tumor of Wolffian origin (FATWO) is an exceedingly rare gynecologic neoplasm characterized by nonspecific clinical manifestations and diagnostic challenges. This article presents a case of an incidentally discovered FATWO in a postmenopausal woman, with a literature review.

A 54-year-old postmenopausal woman was found to have a 5.2-cm solid mass in the left adnexa during routine examination. Ultrasonography revealed a well-circumscribed lesion with detectable blood flow, while computed tomography (CT) scan suggested an ovarian origin. Tumor markers were within normal limits, and the patient remained asymptomatic. Single-port laparoscopic exploration identified a 5-cm solid ovarian nodule with an intact capsule. Intraoperative frozen section analysis suggested FATWO, prompting subsequent total hysterectomy with bilateral salpingo-oophorectomy. No adjuvant therapy was administered postoperatively, and the patient showed no evidence of disease progression during 1-year follow-up.

FATWO exhibits a potentially malignant biological behavior. For postmenopausal patients, total hysterectomy with bilateral salpingo-oophorectomy is recommended. Postoperative management should be individualized. Current evidence regarding treatment strategies for reproductive-age patients remains limited, warranting further investigation to optimize clinical decision-making.

## Linked entities

- **Diseases:** Wolffian tumor (MONDO:0004255), FATWO (MONDO:0004255)

## Full-text entities

- **Diseases:** FATWO (MESH:C536741), gynecologic neoplasm (MESH:D005833), Tumor (MESH:D009369)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

32 references — full list in the complete paper: https://tomesphere.com/paper/PMC12540084/full.md

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Source: https://tomesphere.com/paper/PMC12540084