# Case Report: Novel endoscopic characteristics of early-stage autoimmune gastritis from two cases: the fog is lifting

## TL;DR

This case report presents two early-stage autoimmune gastritis cases with unique endoscopic features to help improve early diagnosis.

## Contribution

The paper introduces two novel endoscopic features for early autoimmune gastritis detection using NBI magnification.

## Key findings

- Deep reticular blood vessels were observed in the lower cardia mucosa of early AIG cases.
- NBI magnification revealed varied crypt opening appearances, including dilation and disappearance.

## Abstract

With the development of research, the clinical characteristics of autoimmune gastritis (AIG) have become much clearer. However, due to its occult endoscopic appearance, it remains difficult to diagnose early, including ultra-early AIG. More cases and typical clinical characteristics should be proposed and concluded to guide clinicians. Hence, we selected two novel cases of early AIG and summarized their common endoscopic features in order to improve diagnostic ability. We found two interesting features for early AIG: 1) deep reticular blood vessels in the lower part of the cardia mucosa and 2) various manifestations of crypt opening shown on narrow-band imaging (NBI) magnification, such as dilation, pinhole-like, shrinkage, and disappearance. Future studies promise even more progress with the hope that these features can be found in more cases.