# Blebbisomes as autonomous communication hubs

**Authors:** Ying Gao, Tiebang Kang

PMC · DOI: 10.20517/evcna.2025.38 · Extracellular Vesicles and Circulating Nucleic Acids · 2025-07-11

## TL;DR

Blebbisomes are special vesicles that act as communication hubs between cells by taking in and releasing other vesicles.

## Contribution

The paper introduces blebbisomes as novel extracellular vesicles capable of internalizing and secreting other vesicles.

## Key findings

- Blebbisomes are a new class of large extracellular vesicles.
- They can internalize and secrete other extracellular vesicles.
- They function as intermediaries in intercellular communication.

## Abstract

Blebbisomes represent a newly identified class of large extracellular vesicles (EVs) that exhibit unique functional capabilities in intercellular communication. Beyond their motility, blebbisomes engage in complex vesicle trafficking functions. Strikingly, they are capable of both internalizing and secreting other EVs, essentially acting as intermediaries or “hubs” in intercellular communication networks.

## Full-text entities

- **Genes:** PDCD1LG2 (programmed cell death 1 ligand 2) [NCBI Gene 80380] {aka B7DC, Btdc, CD273, PD-L2, PDCD1L2, PDL2}, SDCBP (syndecan binding protein) [NCBI Gene 6386] {aka MDA-9, MDA9, SDCBP1, ST1, SYCL, TACIP18}, CD47 (CD47 molecule) [NCBI Gene 961] {aka IAP, MER6, OA3}, MYH14 (myosin heavy chain 14) [NCBI Gene 79784] {aka DFNA4, DFNA4A, FP17425, MHC16, MYH17, NMHC II-C}, CD274 (CD274 molecule) [NCBI Gene 29126] {aka ADMIO5, B7-H, B7H1, PD-L1, PDCD1L1, PDCD1LG1}, EREG (epiregulin) [NCBI Gene 2069] {aka EPR, ER, Ep}, NT5E (5'-nucleotidase ecto) [NCBI Gene 4907] {aka CALJA, CD73, E5NT, NT, NT5, NTE}, CD276 (CD276 molecule) [NCBI Gene 80381] {aka 4Ig-B7-H3, B7-H3, B7H3, B7RP-2}, TSG101 (tumor susceptibility 101) [NCBI Gene 7251] {aka TSG10, VPS23}, VSIR (V-set immunoregulatory receptor) [NCBI Gene 64115] {aka B7-H5, B7H5, C10orf54, DD1alpha, Dies1, GI24}, KLRC1 (killer cell lectin like receptor C1) [NCBI Gene 3821] {aka CD159A, NKG2, NKG2A}, HLA-E (major histocompatibility complex, class I, E) [NCBI Gene 3133] {aka HLA-6.2, QA1}
- **Diseases:** cancer (MESH:D009369)
- **Chemicals:** ATP (MESH:D000255), lipids (MESH:D008055)
- **Species:** Homo sapiens (human, species) [taxon 9606], Mus musculus (house mouse, species) [taxon 10090]
- **Cell lines:** B16-F1 — Mus musculus (Mouse), Mouse melanoma, Cancer cell line (CVCL_0158)

## Full text

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## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12540046/full.md

## References

10 references — full list in the complete paper: https://tomesphere.com/paper/PMC12540046/full.md

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Source: https://tomesphere.com/paper/PMC12540046