# Wild-Type Transthyretin Amyloidosis in the Kidneys

## TL;DR

This paper reports the first case of wild-type transthyretin amyloidosis diagnosed in the kidneys, highlighting the disease's rare extracardiac manifestations.

## Contribution

The first documented antemortem diagnosis of kidney involvement in wild-type transthyretin amyloidosis.

## Key findings

- ATTRwt amyloidosis was diagnosed in the kidney vasculature of a patient with progressive kidney failure.
- Technetium-99m pyrophosphate scintigraphy showed no myocardial uptake in this case.
- The case expands the understanding of extracardiac organ involvement in ATTRwt amyloidosis.

## Abstract

Wild-type transthyretin (ATTRwt) amyloidosis typically presents with restrictive cardiomyopathy. Kidney involvement is exceedingly rare. We report to our knowledge the first antemortem diagnosis of ATTRwt amyloidosis with kidney vasculature deposition in a patient presenting with progressive kidney failure. Notably, technetium-99m pyrophosphate scintigraphy showed no myocardial uptake. This case expands the known spectrum of organ involvement in ATTRwt amyloidosis and underscores the need to consider extracardiac manifestations in its diagnosis.