# Amebiasis of the Gallbladder: A Rare Presentation

**Authors:** Eshaan Chandra, Mohit K Badgurjar, Geeta W Mukhiya, Suman Parihar, Neha Pandya

PMC · DOI: 10.7759/cureus.92837 · Cureus · 2025-09-21

## TL;DR

This case report describes a rare instance of amebiasis in the gallbladder, emphasizing the need for histopathological evaluation for accurate diagnosis and treatment.

## Contribution

The novelty lies in presenting a rare clinical case of gallbladder amebiasis and highlighting the importance of histopathology in such diagnoses.

## Key findings

- Amebiasis caused by Entamoeba histolytica was diagnosed in the gallbladder through histopathology.
- Treatment with metronidazole led to a full recovery in the patient.
- The case underscores the importance of histopathological examination in rare gallbladder conditions.

## Abstract

Amebiasis is caused by Entamoeba histolytica, commonly found in the liver and colon. Its presentation is rare in the gallbladder. A 25-year-old female presented with epigastric pain radiating towards the right hypochondrium. The patient was diagnosed with calculous cholecystitis. Later on, performing a laparoscopic cholecystectomy, histopathology resulted in acute-on-chronic necrotizing cholecystitis with E. histolytica trophozoites. The treatment included metronidazole 500 mg thrice daily for 14 days, resulting in full healthy recovery. This case report highlights the importance of considering a histopathological examination when evaluating rare gallbladder pathologies and treating them with accurate treatment.

## Linked entities

- **Chemicals:** metronidazole (PubChem CID 4173)
- **Diseases:** amebiasis (MONDO:0005644)
- **Species:** Entamoeba histolytica (taxon 5759)

## Full-text entities

- **Diseases:** Amebiasis (MESH:D000562), acute-on-chronic necrotizing cholecystitis (MESH:D041881), epigastric pain (MESH:D010146), gallbladder pathologies (MESH:D005705), calculous cholecystitis (MESH:D002764)
- **Chemicals:** metronidazole (MESH:D008795)
- **Species:** Entamoeba histolytica (species) [taxon 5759], Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12539330/full.md

## References

10 references — full list in the complete paper: https://tomesphere.com/paper/PMC12539330/full.md

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Source: https://tomesphere.com/paper/PMC12539330