# Egg intake and cognitive function in healthy adults: A systematic review of the literature

**Authors:** Nessmah Sultan, Nicole J. Kellow, Caroline J. Tuck, Edellyne Cheng, Clare MacMahon, Jessica R. Biesiekierski

PMC · DOI: 10.1016/j.jnha.2025.100696 · The Journal of Nutrition, Health & Aging · 2025-10-07

## TL;DR

This review examines how eating eggs affects cognitive function in healthy adults, finding mixed results but suggesting moderate egg intake may help reduce dementia risk and improve memory.

## Contribution

The study provides a systematic review of whole egg consumption's impact on cognitive function, highlighting gaps in current research.

## Key findings

- Moderate egg consumption may reduce dementia risk and improve memory in older adults.
- High egg intake may increase dementia risk in some populations.
- Cognitive benefits were observed with moderate egg intake but not with high levels.

## Abstract

Cognitive decline is a growing public health concern, particularly in aging populations. Eggs are a widely consumed, nutrient-dense food containing choline, phospholipids, tryptophan, and omega-3 fatty acids, which individually support cognitive processes such as memory, attention, and neurogenesis. While these individual nutrients have demonstrated benefits in supplementation studies, the cognitive effects of whole egg consumption are not well established. This systematic review aimed to evaluate the association between whole egg consumption and cognitive function in healthy adults.

A systematic search of five electronic databases (Medline, Embase, CINAHL Plus, SCOPUS, and PsychInfo) was conducted from database inception through February 2025. Studies were included if they investigated whole egg intake in relation to cognitive outcomes in healthy adults. Risk of bias was assessed using tools appropriate to study design. Due to heterogeneity in study methods, outcomes were synthesised narratively. Cognitive outcomes were categorised into domains including global cognitive function, memory, executive function, language, processing speed, and dementia risk.

Eleven studies met the inclusion criteria: one pre-post intervention study, six prospective cohort studies, three cross-sectional studies, and one case-control study. Study populations were predominantly older adults and included >38,000 participants. Two studies reported a reduced risk of dementia or cognitive impairment associated with moderate egg consumption (approximately 0.5–1 egg per day), while one study found increased risk at high intake levels (Over 1 egg per day). Several studies showed improvements in memory, verbal fluency, or processing speed with moderate—but not high—egg intake. The pre-post study reported improved reaction time following eight weeks of daily egg consumption (2 eggs per day). Heterogeneity in exposure measurement and cognitive testing methods limited direct comparisons across studies.

Moderate whole egg consumption may be associated with improvements in cognitive outcomes in healthy adults, including reduced dementia risk and better memory performance. However, findings are inconsistent and limited by differences in study design, dietary assessment, and cognitive testing. Further well-controlled intervention studies are needed to determine optimal intake levels, explore mechanisms, and assess whether eggs can be integrated meaningfully into dietary strategies to support cognitive aging. (PROSPERO registration: 408532).

## Linked entities

- **Diseases:** dementia (MONDO:0001627)

## Full-text entities

- **Diseases:** dementia (MESH:D003704), Cognitive decline (MESH:D003072)
- **Chemicals:** choline (MESH:D002794), phospholipids (MESH:D010743), tryptophan (MESH:D014364), omega-3 fatty acids (MESH:D015525)

## Full text

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## Figures

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## References

71 references — full list in the complete paper: https://tomesphere.com/paper/PMC12538690/full.md

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Source: https://tomesphere.com/paper/PMC12538690