# Unsolved Issues in Anhedonia: A Call for Targeted Inquiry

**Authors:** Maria Luca, Antonina Luca, Alessandro Serretti

PMC · DOI: 10.62641/aep.v53i5.1993 · Actas Españolas de Psiquiatría · 2025-10-05

## Full-text entities

- **Genes:** TNF (tumor necrosis factor) [NCBI Gene 7124] {aka DIF, IMD127, TNF-alpha, TNFA, TNFSF2, TNLG1F}, IL6 (interleukin 6) [NCBI Gene 3569] {aka BSF-2, BSF2, CDF, HGF, HSF, IFN-beta-2}, CRP (C-reactive protein) [NCBI Gene 1401] {aka PTX1}
- **Diseases:** motivational deficits (MESH:D009461), Depression (MESH:D003866), Anhedonia (MESH:D059445), vascular dementia (MESH:D015140), Parkinson's disease (MESH:D010300), inflammation (MESH:D007249), neurodegenerative disorders (MESH:D019636), psychiatric (MESH:D001523), MDD (MESH:D003865), autism spectrum disorder (MESH:D000067877), attention-deficit hyperactivity disorder (MESH:D001289)
- **Chemicals:** ketamine (-), psilocybin (MESH:D011562), endocannabinoid (MESH:D063388)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

15 references — full list in the complete paper: https://tomesphere.com/paper/PMC12538609/full.md

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Source: https://tomesphere.com/paper/PMC12538609