# Regiodivergent Deuteration of Pyridine-Based Heterocycles

## TL;DR

This paper introduces a new method to selectively add deuterium atoms to specific sites in pyridine-based compounds using mild conditions.

## Contribution

A regiodivergent deuteration method for pyridotriazoles is introduced, enabling site-selective labeling under mild conditions.

## Key findings

- Site-selective deuteration can be controlled by adjusting base and solvent.
- Pyridotriazoles can be easily converted into various pyridine derivatives.
- The method allows predictable and selective deuteration of pyridine heterocycles.

## Abstract

Herein, we describe a regiodivergent deuteration of pyridotriazoles
under mild conditions. Site-selective deuteration can be tuned, controlled,
and switched by a subtle interplay of the base and solvent utilized.
Given the ease at which pyridotriazoles can be converted into a variety
of pyridine congeners, this protocol might offer a new gateway to
access a variety of deuterium-labeled pyridine-containing heterocycles
in a site-selective, yet predictable, manner.