# C. Diff-erently: evaluating the association of inappropriate antibiotic use with hospital-onset Clostridioides difficile infection

## TL;DR

This study examines whether inappropriate antibiotic use is linked to hospital-onset Clostridioides difficile infection in a New York City hospital.

## Contribution

The study evaluates the association between inappropriate antibiotic use and hospital-onset C. difficile infection in an inpatient setting.

## Key findings

- Elevated or inappropriate antibiotic use was not associated with hospital-onset C. difficile infection.
- The study compared antibiotic use in C. difficile cases to matched controls in an inpatient setting.

## Abstract

Hospital-onset C. difficile infection (HO-CDI) remains a common cause of healthcare-associated infection. This study evaluated antibiotic use (AU) and appropriateness in hospital-onset C. difficile cases compared to matched controls in an inpatient setting at a New York City hospital. Elevated or inappropriate AU was not associated with HO-CDI.