# Case Report: Synchronous primary location of gastrointestinal stromal tumors (GIST) and adenocarcinoma of the colon: an unusual occurrence

## TL;DR

This case report describes a rare occurrence of a gastrointestinal stromal tumor and colon cancer appearing together in the same patient.

## Contribution

The paper presents a unique clinical case of synchronous GIST and colonic adenocarcinoma, highlighting the need for further research into their co-occurrence.

## Key findings

- A patient had both a GIST and colonic adenocarcinoma, confirmed through histologic and immunohistochemical analysis.
- The patient underwent successful surgical resection with no tumor recurrence observed at one-year follow-up.
- The paper suggests that the pathogenesis of these two tumors may differ, requiring further genetic and therapeutic investigation.

## Abstract

Background: We have little knowledge about the synchronous occurrence of gastrointestinal stromal tumors (GISTs) and other types of histologic tumors. This association is very rare.

Case presentation: We describe a case of synchronous stromal tumor and adenocarcinoma of the left side colonic localization. Immunohistochemistry identified c-Kit expression. The discovery of colonic adenocarcinoma was on operative specimen after histologic examination. The patient underwent left carcinologic colectomy with stoma. Follow-up at one year postoperatively did not detect tumor recurrence.

Discussion: Clinical implications of the association between these two neoplasms are not clearly described. Treatment depends on the dominance of one histologic type. Knowledge of the genetic data of this association offers opportunity of treatment with the new targeted-therapy molecules. Surgical resection, may remain the curative treatment.

Conclusions: Synchronous adenocarcinoma and GIST has been more commonly described in the stomach.  The pathogeneses of tumorigenesis may not be the same for the two tumors. More studies seem be necessary to clarify a potential role of different genes in the development of adenocarcinomas. And therefore, above all their therapeutic implications