# Necrotizing Fasciitis of Eyelid in Children: A Rare Complication of Varicella Infection

**Authors:** Govinda Bhandari, Himal Acharya, Richa Paudyal

PMC · DOI: 10.1002/ccr3.71334 · Clinical Case Reports · 2025-10-21

## TL;DR

A rare case of eyelid necrotizing fasciitis in a child following a varicella infection is reported, highlighting the need for prompt treatment.

## Contribution

This paper presents a rare clinical case of eyelid necrotizing fasciitis following varicella in a child, emphasizing treatment strategies.

## Key findings

- Necrotizing fasciitis of the eyelid can occur as a rare complication of varicella in children.
- Aggressive antibiotic therapy and surgical debridement led to successful recovery in this case.
- Coagulase-negative Staphylococcus, Enterococcus, and Acinetobacter baumannii were identified in cultures.

## Abstract

Necrotizing fasciitis (NF) of the eyelid is an extremely rare but severe complication of varicella zoster virus (VZV) infection in children. We present a case of an 8‐year‐old girl who developed necrotizing fasciitis of the left eyelid following varicella infection. The patient initially presented with fever, vesicular rashes, and swelling of the left peri‐orbital region. She was treated with oral acyclovir (400 mg five times daily for 7 days) and prednisolone (10 mg daily for 5 days) at a local medical store. Due to worsening symptoms, she was admitted to our center where intravenous antibiotics—Meropenem (40 mg/kg/dose every 8 h) and Vancomycin (15 mg/kg/dose every 6 h)—were administered for 21 days, followed by oral levofloxacin (250 mg once daily for 2 weeks). Surgical debridement of necrotic tissue was performed. Cultures revealed Coagulase‐negative Staphylococcus, Enterococcus, and later 
Acinetobacter baumannii
. The patient responded well to treatment and showed healthy healing in follow‐up. This case emphasizes the importance of early surgical intervention, aggressive antibiotic therapy, and multidisciplinary care in managing rare but severe complications like periorbital necrotizing fasciitis secondary to varicella. Key clinical findings included progressive periorbital necrosis, culture results, and favorable response to combined medical and surgical therapy.

## Linked entities

- **Chemicals:** acyclovir (PubChem CID 135398513), prednisolone (PubChem CID 5755), Meropenem (PubChem CID 441130), Vancomycin (PubChem CID 14969), levofloxacin (PubChem CID 149096)
- **Diseases:** varicella (MONDO:0005700), necrotizing fasciitis (MONDO:0004835), varicella zoster virus infection (MONDO:0005608)

## Full-text entities

- **Diseases:** Varicella Infection (MESH:D002644), VZV (MESH:D000073618), NF (MESH:D019115), infection (MESH:D007239), necrotic (MESH:D009336), periorbital necrosis (MESH:D006261), swelling (MESH:D004487), fever (MESH:D005334), vesicular rashes (MESH:D005076)
- **Chemicals:** Vancomycin (MESH:D014640), prednisolone (MESH:D011239), Meropenem (MESH:D000077731), levofloxacin (MESH:D064704), acyclovir (MESH:D000212)
- **Species:** Homo sapiens (human, species) [taxon 9606], Staphylococcus (genus) [taxon 1279], Enterococcus (genus) [taxon 1350], Acinetobacter baumannii (species) [taxon 470]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12538151/full.md

## References

13 references — full list in the complete paper: https://tomesphere.com/paper/PMC12538151/full.md

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Source: https://tomesphere.com/paper/PMC12538151