# Aripiprazole-induced reversible myopia in a patient with tourette syndrome

## TL;DR

Aripiprazole, a medication for neuropsychiatric conditions, can cause reversible myopia, which improved when the dose was reduced.

## Contribution

This case report adds a new case of aripiprazole-induced reversible myopia and suggests a possible dose-dependent mechanism.

## Key findings

- A 29-year-old woman with Tourette syndrome developed bilateral myopia while taking aripiprazole.
- Her myopia regressed after reducing the aripiprazole dose from 15 mg to 10 mg daily.
- Eleven cases of aripiprazole-induced reversible myopia have been reported, mostly in young females.

## Abstract

Myopia has been reported as a rare adverse effect of aripiprazole, a third-generation antidopaminergic medication used for the treatment of different neuropsychiatric conditions, including psychotic disorders, affective disorders, and obsessive-compulsive disorder.

We document the rare case of a 29-year-old woman diagnosed with a neurodevelopmental tic disorder (Tourette syndrome) who developed bilateral myopia while taking aripiprazole 15 mg daily as a first-line anti-tic agent. Her myopia completely regressed following a decrease in the dose of aripiprazole from 15 mg to 10 mg daily.

To date, a total of 11 cases presenting with aripiprazole-induced reversible myopia (9 females, age range 19–34 years) have been reported. In addition to broadening the spectrum of the treated conditions, our case report raises the possibility of dose-dependent mechanisms underlying the development of myopia, at least in selected cases.