# Correlating the triglyceride glucose index with short-term neurological and functional prognosis following intravenous thrombolysis in acute ischemic stroke patients

## TL;DR

This study finds that a blood sugar and fat measure called the TyG index is linked to recovery outcomes in stroke patients treated with clot-busting drugs.

## Contribution

The study identifies the TyG index as a novel potential prognostic marker for short-term neurological and functional recovery in acute ischemic stroke patients after thrombolysis.

## Key findings

- The TyG index significantly correlates with NIHSS scores at discharge (rho = 0.45, p < 0.01).
- Higher TyG index values are associated with poor functional outcomes (OR = 1.89, p = 0.005).
- The TyG index is linked to neurological non-improvement after adjusting for confounders (OR = 2.11, p = 0.002).

## Abstract

To assess the correlation between the triglyceride glucose (TyG) index and short-term neurological and functional outcomes in patients with acute ischemic stroke (AIS) post-intravenous thrombolysis (IVT).

This prospective observational study included AIS patients treated with IVT within 4.5 h from symptom onset. The TyG index was calculated using fasting triglyceride and glucose levels. Neurological improvement was evaluated by a reduction in National Institutes of Health Stroke Scale (NIHSS) scores, and functional outcome by modified Rankin Scale (mRS) at discharge. Statistical analysis included correlation and regression analyses.

Among 150 AIS patients, the TyG index significantly correlated with both NIHSS (rho = 0.45, p < 0.01) and mRS (rho = 0.38, p < 0.01) scores at discharge. A higher TyG index was associated with neurological non-improvement (OR = 2.11, p = 0.002) and poor functional outcomes (OR = 1.89, p = 0.005) after adjustment for confounders.

The TyG index is significantly associated with short-term outcomes in AIS patients post-IVT, suggesting its potential as a prognostic marker for stroke severity and recovery. Future studies with larger cohorts are needed to confirm these findings.