# Case Report: Uncommon co-occurrence of different renal histopathological entities in a patient with multiple myeloma and lymphoplasmacytic lymphoma

## TL;DR

A patient with multiple myeloma and lymphoplasmacytic lymphoma had multiple kidney injuries, but improved after treatment.

## Contribution

This case report highlights the rare coexistence of multiple renal histopathologies in a patient with plasma cell dyscrasias.

## Key findings

- The patient had multiple myeloma and lymphoplasmacytic lymphoma with concurrent kidney injuries.
- Anti-myeloma therapy led to a good hematologic response and dialysis independence.
- Coexisting renal damages are uncommon and may have worse outcomes.

## Abstract

In patients with plasma cell dyscrasias presenting with kidney injury, renal biopsy usually displays the presence of a single histological damage. However, the coexistence of heterogeneous damages has been occasionally described and is associated with worse renal outcomes. In this report, we describe the case of a patient with a concomitant diagnosis of multiple myeloma and lymphoplasmacytic lymphoma, presenting with acute kidney injury and with renal biopsy revealing the unexpected concurrent presence of several different renal damages, who achieved a good hematologic response and dialysis independence after anti-myeloma therapy.