# A scientometric analysis of global research on gut microbiota and glioma

**Authors:** Lize Chen, Kun Shu, Zhiyin Zhang, Jiao Zhao

PMC · DOI: 10.3389/fonc.2025.1646187 · Frontiers in Oncology · 2025-10-07

## TL;DR

This paper analyzes global research trends on gut microbiota and glioma using bibliometric methods to identify leading countries, institutions, and emerging research topics.

## Contribution

The study provides the first systematic bibliometric analysis of gut microbiota and glioma research, visualizing trends and identifying future research directions.

## Key findings

- China and the United States are leading in gut microbiota and glioma research.
- The brain-gut axis and enteric nervous system mechanisms are prominent research hotspots.
- The receptor tyrosine kinase pathway is identified as a promising area for future research.

## Abstract

Most previous studies have demonstrated that gut microbiota is closely related to the prognosis of glioma. However, there is currently no corresponding bibliometric analysis to systematically review, analyze, and visualize prior research.

This study focused on 127 publications obtained from the Web of Science Core Collection and conducted correlation analyses of authors, journals, institutions, countries, keywords, and citations using VOSviewer, CiteSpace, and the R package.

The results indicate that China and the United States are the leading countries conducting research in this field. The Anderson Cancer Center at the University of Texas in the United States and Central South University in China are the primary research institutions.

Recent studies suggest that the regulation of the brain-gut axis between gut microbiota and glioma remains a prominent research hotspot, while the anti-cancer mechanisms of the enteric nervous system and gut microbiota have emerged as significant topics in recent years. Furthermore, the receptor tyrosine kinase pathway is expected to provide extensive research opportunities in the future. This article systematically reviews the current research status and hotspots of gut microbiota in glioma for the first time, conducts a visual analysis, and explores research trends and future directions.

## Linked entities

- **Diseases:** glioma (MONDO:0021042)

## Full-text entities

- **Genes:** RET (ret proto-oncogene) [NCBI Gene 5979] {aka CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1}
- **Diseases:** glioma (MESH:D005910), Anderson (MESH:C535460), Cancer (MESH:D009369)

## Full text

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## Figures

11 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12537380/full.md

## References

33 references — full list in the complete paper: https://tomesphere.com/paper/PMC12537380/full.md

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Source: https://tomesphere.com/paper/PMC12537380