# RNA Interference of the Genes Associated with the Invasion of Brain Tumor Cells

## TL;DR

This review discusses how RNA interference can target genes involved in brain tumor cell invasion, potentially reducing cancer spread.

## Contribution

The paper reviews RNA interference strategies to modulate signaling pathways linked to glioblastoma cell invasion.

## Key findings

- RNA interference can reduce the invasive and proliferative potentials of glioblastoma cells.
- Targeted genes are involved in key signaling pathways like p53 and JAK-STAT.
- Delivery of interfering RNAs remains a major challenge in clinical application.

## Abstract

High-grade gliomas are among the most aggressive malignant pathologies of the
brain. The high invasive potential of tumor cells causes relapses of the
disease even after radical resection of the tumor. The signatures of the genes
associated with the invasion of glioma cells have now been identified. The
expression products of these genes are involved in various signaling pathways,
such as cellular protein catabolism, the p53 signaling pathway, transcription
dysregulation, and the JAK-STAT signaling pathway. Therefore, they can
indirectly modulate the invasive potential of tumor cells. Using RNA
interference technology, it is possible to change the expression level of the
detected genes and reduce the invasive and proliferative potentials of cancer
cells. This review focuses on the use of this technology to influence various
links in signaling pathways and, accordingly, the cellular processes associated
with the invasion of glioblastoma cells. Furthermore, the review discusses the
problems associated with delivering interfering RNAs into cells and ways to
solve them.