# Small Bowel Adenocarcinoma Masquerading as Crohn’s Disease

**Authors:** Se Yeon Kim, Brandon Wiggins, Daniel Ramirez, Mark Minaudo

PMC · DOI: 10.7759/cureus.92797 · Cureus · 2025-09-20

## TL;DR

A rare case of small bowel adenocarcinoma was initially mistaken for Crohn’s disease, emphasizing the need for accurate diagnosis to avoid complications.

## Contribution

This case report highlights the diagnostic challenge of small bowel adenocarcinoma mimicking Crohn’s disease.

## Key findings

- A 46-year-old female presented with symptoms resembling Crohn’s disease but was diagnosed with small bowel adenocarcinoma.
- Histopathology confirmed invasive adenocarcinoma at the ileocecal valve despite initial suspicion of Crohn’s disease.

## Abstract

Small bowel adenocarcinoma (SBA) is a rare gastrointestinal malignancy, with the majority of cases seen in the duodenum. SBA often poses a diagnostic challenge due to its non-specific presentation. A 46-year-old female smoker presented with a 6-week history of persistent abdominal pain and nausea. The initial workups, including computed tomography and colonoscopy, demonstrated evidence of suspected Crohn’s disease (CD). The histopathology of an ileocecal valve ulcer revealed invasive adenocarcinoma. Our case highlights the necessity of considering SBA in the differential diagnosis for patients exhibiting symptoms similar to Crohn's disease, as delays in diagnosis and treatment may result in disease progression and complications, including small bowel obstruction.

## Linked entities

- **Diseases:** Crohn’s disease (MONDO:0005011), small bowel adenocarcinoma (MONDO:0003198)

## Full-text entities

- **Diseases:** abdominal pain (MESH:D015746), nausea (MESH:D009325), ulcer (MESH:D014456), small bowel obstruction (MESH:D007409), CD (MESH:D003424), SBA (MESH:D000230), gastrointestinal malignancy (MESH:D005770)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12536946/full.md

## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12536946/full.md

## References

7 references — full list in the complete paper: https://tomesphere.com/paper/PMC12536946/full.md

---
Source: https://tomesphere.com/paper/PMC12536946