# Visualizing the Global Landscape of Post-transplant Acute Lung Rejection

## TL;DR

This paper reviews global research trends on post-lung-transplant acute rejection, focusing on antibody-mediated rejection and its impact on patient outcomes.

## Contribution

The study provides a bibliometric analysis of lung transplant rejection research from 2016 to 2025, highlighting emerging trends and knowledge gaps.

## Key findings

- Antibody-mediated rejection remains a significant challenge in lung transplantation.
- Bibliometric analysis reveals key research trends and collaboration patterns in the field.
- Persistent rejection and treatment limitations affect long-term survival rates.

## Abstract

After lung transplantation, prior antibodies can rapidly attack the donor lung, causing damage and increasing acute rejection risk, specifically known as antibody-mediated rejection. While antibody matching has improved, numerous challenges remain in detecting and treating rejection. The lung’s exposure to its surroundings further activates immune responses. Persistent rejection and aggressive treatments can reduce survival rates. This review is a bibliometric analysis encompassing research on lung transplants and rejection published between 2016 and 2025. Insights were obtained by extracting elements from citation analysis from the Web of Science database and outlining emerging patterns and trends using VOSviewer (version 1.6.15; Leiden University, Leiden, The Netherlands). The analysis encompasses countries, institutions, publication years, and keywords that comprise the literature on acute rejection following lung transplantation.