# Comparative in vivo PET imaging of silica microparticles: shape-dependent blood circulation and short-term biodistribution

## TL;DR

This paper uses PET imaging in mice to show that silica particles of different shapes have different distributions in the body, suggesting shape can influence targeting.

## Contribution

The study demonstrates shape-dependent biodistribution of silica microparticles using in vivo PET imaging in mice.

## Key findings

- Silica rods and spheres (∼1 μm) showed different biodistributions in mice.
- PET imaging revealed shape-dependent in vivo behavior after intravenous administration.

## Abstract

Particles at the nanometric–micrometric interface hold promise by combining the drug-loading capacity of microparticles with the systemic benefits of nanoparticles. We assess the in vivo behaviour in mice via PET imaging of silica rods and spheres (∼1 μm), showing different biodistributions thus highlighting the potential for shape-dependent targeting.

We compare the in vivo behaviour in mice via PET imaging of silica rods and spheres (∼1 μm) after intravenous administration, showing different biodistributions and highlighting the potential for shape-dependent targeting.