# Carney Complex During Six-Year Follow-Up and Its Association With Attention-Deficit Hyperactivity Disorder: A Case Report

## TL;DR

A young boy with Carney complex showed improvement in Cushing's syndrome and precocious puberty after treatment, but also had attention-deficit hyperactivity disorder.

## Contribution

This case report highlights the association of attention-deficit hyperactivity disorder with Carney complex and the effectiveness of multidrug therapy for precocious puberty.

## Key findings

- The patient showed complete relief from Cushing's syndrome and improved predicted adult height after treatment.
- Attention-deficit hyperactivity disorder was identified as a comorbid condition in the patient.
- Multidrug combination therapy was effective in managing precocious puberty.

## Abstract

Carney complex is a rare autosomal dominant genetic syndrome that may involve multiple endocrine glands. As the disease progresses, different symptoms gradually emerge. Follow-up is crucial for early diagnosis and treatment of each neoplasm. Case report: A 3.8-year-old Han Chinese male patient presented with acne for one year. He was diagnosed with Carney complex for Cushing's syndrome caused by an adrenal adenoma, precocious puberty mainly caused by a large cell calcifying Sertoli cell tumour of the testis. Left adrenalectomy and a treatment for precocious puberty, including aromatase inhibitor therapy, were prescribed. The patient experienced complete relief from Cushing's syndrome and showed an improvement in predicted adult height. Attention-deficit hyperactivity disorder impaired the patient's attention. Both the patient and his parents were receiving behavior management training. Carney complex patients need close follow-up. Adrenal adenoma is also a possible pathological type of adrenal lesion in this complex. Multidrug combination therapy could have a good effect on precocious puberty. Attention-deficit hyperactivity disorder was present as a comorbid condition, the underlying mechanism of which in patients with Carney complex requires further investigation. Collaboration among multidisciplinary teams is crucial for prognosis.