# Research advance in correlation between childhood asthma and gut microbiota

## TL;DR

This review explores how gut bacteria influence childhood asthma and how targeting these microbes could lead to new treatments.

## Contribution

The paper synthesizes clinical and mechanistic evidence on gut microbiota's role in childhood asthma and potential interventions.

## Key findings

- Gut microbiota like Lactobacillus and Bifidobacterium are linked to childhood asthma.
- Probiotics and SCFAs can restore microbial balance and reduce inflammation.
- Phytogenic compounds may reshape gut microbiota and ease asthma symptoms.

## Abstract

Asthma remains a highly prevalent and heterogeneous chronic respiratory disease in the pediatric population. Accumulating evidence has established a critical role of the gut–lung axis in the pathogenesis of asthma. Specifically, gut microbiota constituents such as Lactobacillus and Bifidobacterium species have been closely associated with childhood asthma. Current intervention strategies targeting the gut microbiota show considerable promise. Probiotic supplementation and short-chain fatty acids (SCFAs) have demonstrated the ability to restore microbial homeostasis and suppress type 2 inflammation. Additionally, phytogenic compounds exhibit potential in reshaping the gut microbial composition and ameliorating asthma symptoms. This review synthesizes clinical and mechanistic evidence from both human and animal studies, highlighting the translational potential of microbiota-targeted therapies. Future research should prioritize the development of personalized microbiota-based interventions to improve clinical outcomes in children with asthma.