# A case report of gastric serrated adenoma arising in a patient with bile reflux gastritis and related literature review

**Authors:** Chang Cai, Liping Yan, Kuang-I Fu, Bin Ye, Yixiu Shao, Han Wang, Qin Xu, Lixia Fu

PMC · DOI: 10.3389/fonc.2025.1670442 · Frontiers in Oncology · 2025-10-06

## TL;DR

This paper reports a rare case of gastric serrated adenoma in a patient with bile reflux gastritis and suggests a possible link between the two.

## Contribution

The first documented case of gastric serrated adenoma arising in a background of bile reflux gastritis.

## Key findings

- A 70-year-old male had a gastric serrated adenoma confirmed via histopathology.
- The lesion was found in a background of bile reflux gastritis.
- Bile reflux may be a potential risk factor for gastric serrated adenoma.

## Abstract

Serrated adenoma is often found in the colorectum, but seldom found in stomach. We reported a case of a 70-year-old male with gastroscopy showed an elevated lesion with central depression on the gastric body, with clear margins. Background consistent with bile reflux gastritis. Endoscopic submucosal dissection (ESD) was performed. Histopathology confirmed a gastric serrated adenoma. This study reports the first documented case of gastric serrated adenoma arising in a background of bile reflux gastritis, suggesting bile reflux may be a potential risk factor for gastric serrated adenoma development.

## Full-text entities

- **Diseases:** bile reflux (MESH:D001655), depression (MESH:D003866), Serrated adenoma (MESH:D000236)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12535884/full.md

## References

20 references — full list in the complete paper: https://tomesphere.com/paper/PMC12535884/full.md

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Source: https://tomesphere.com/paper/PMC12535884