# The efficacy and potential mechanism of the acupuncture treatment for type 2 diabetes mellitus: A systematic review and meta-analysis of data from animal models

## TL;DR

This study reviews animal research to show that acupuncture can lower blood sugar and improve lipid levels in type 2 diabetes models.

## Contribution

The first comprehensive meta-analysis evaluating acupuncture's effects on T2DM in animal models and its potential mechanisms.

## Key findings

- Acupuncture significantly reduced blood glucose, body weight, triglycerides, and total cholesterol in T2DM animal models.
- No significant effect was observed on high-density lipoprotein levels in the studied models.
- The results suggest acupuncture may be a promising treatment for improving metabolic profiles in T2DM.

## Abstract

Type 2 diabetes mellitus (T2DM) is a prevalent metabolic disorder with limited treatment options. Manual acupuncture and electroacupuncture have been investigated in numerous animal studies for their potential to improve glycemic and lipid profiles, but no comprehensive synthesis exists. This review aims to evaluate the effects of manual acupuncture and electroacupuncture on blood glucose and lipid levels in animal models of T2DM, and to explore potential mechanisms.

A systematic search was conducted in PubMed, Embase, Cochrane, Web of Science, and major Chinese databases from inception to December 2024. Only animal studies employing manual acupuncture or electroacupuncture for T2DM models were included. The methodological quality was assessed using a 10-item CAMARADES checklist. Meta-analyses were performed using STATA 17.0, and subgroup analyses explored the influence of modeling methods, intervention timing, and treatment duration.

A total of 14 studies with 274 animals with T2DM were included. The overall quality of the included reports was rated as moderate or higher. Meta-analysis showed that acupuncture significantly reduced blood glucose [Standardized Mean Difference(SMD)= -3.15, 95% Confidence Interval(CI) (-4.18, -2.12), I-squared (I²)= 85.1%, (P< 0.05)], body weight [SMD = -3.36, 95%CI (-4.77, -1.95), I²= 84.2%,(P<0.05)], triglycerides [SMD=-2.50, 95% CI (-3.00, -2.01), I²= 0.0%, (P< 0.05)], total cholesterol [SMD = -2.60, 95% CI (-3.55,-1.65), I²= 74.9%, (P< 0.05)], and low-density lipoprotein [SMD = -3.36, 95%CI (-5.42,-1.95), I²= 86.2%] (P< 0.05)], and no statistically significant difference was observed in high-density lipoprotein [SMD = 0.61, 95% CI (-0.98, 2.19), I² = 92.1%, (P> 0.05)] compared to the control group. These results suggest that acupuncture can effectively improve blood glucose and lipid levels in animal models of T2DM.

While this study is limited by the number of included studies, the results indicate that acupuncture can effectively improve blood glucose and lipid levels in animal models of T2DM.

https://www.crd.york.ac.uk/prospero/, identifier CRD42024520000.