# Navigating Challenges in Mixed Malaria Infections: A Case of Mixed Plasmodium falciparum and Plasmodium vivax Infection in a Patient With Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency

## TL;DR

This paper reports a rare case of mixed malaria infection in a patient with a genetic condition that complicates treatment.

## Contribution

The novelty lies in documenting a mixed Plasmodium falciparum and Plasmodium vivax infection in a G6PD-deficient patient.

## Key findings

- Mixed malaria infection was confirmed using PCR in a patient with G6PD deficiency.
- The patient responded well to a treatment regimen including artesunate, artemether/lumefantrine, and primaquine.

## Abstract

Malaria continues to be a significant health issue in various regions worldwide, including Malaysia. It is a vector-borne disease transmitted primarily by Anopheles mosquitoes. Mixed malaria infections are rarely reported and often underestimated globally. Early diagnosis is essential for timely treatment, which improves outcomes and reduces morbidity. We report a case of imported mixed malaria infection in a patient with glucose-6-phosphate dehydrogenase deficiency, in whom Plasmodium falciparum and Plasmodium vivax were identified through malaria PCR. The patient’s condition improved after completing a full course of IV artesunate, oral Riamet (artemether/lumefantrine), and primaquine.