# Clinical Outcomes of In Vitro Fertilization (IVF) Versus Intrauterine Insemination (IUI) in Infertile Patients: Toward Evidence-Based Fertility Planning

## TL;DR

This study compares IVF and IUI for infertility, finding that IVF leads to better pregnancy and live birth rates, especially in younger women.

## Contribution

The study provides evidence-based insights into the effectiveness of IVF versus IUI, supported by statistical and machine learning analyses.

## Key findings

- IVF had higher pregnancy and live birth rates than IUI (46% vs 33.3% and 40.7% vs 27.3%).
- AMH and FSH were significant predictors of pregnancy outcomes.
- A random forest model predicted outcomes with 73.1% accuracy.

## Abstract

Background

Infertility poses a significant reproductive health burden, and assisted reproductive technologies (ART) such as intrauterine insemination (IUI) and in vitro fertilization (IVF) are widely used treatments. This study aimed to compare the clinical outcomes of IVF and IUI in infertile women to inform evidence-based fertility planning.

Methods

A total of 300 infertile women were analyzed, evenly distributed into IVF (150, 50%) and IUI (150, 50%) groups. Baseline demographics, hormonal markers, and infertility characteristics were assessed. Clinical outcomes, including pregnancy and live birth rates, were compared. Statistical analyses included t-tests, chi-squared tests, correlation analysis, logistic regression, and machine learning modeling.

Results

The overall clinical pregnancy rate was 119 (39.7%). IVF yielded a significantly higher pregnancy rate (69, 46%) compared to IUI (50, 33.3%) (χ²=4.15; p=0.042). Similarly, live birth was more frequent in the IVF group (61, 40.7%) than the IUI group (41, 27.3%) (χ²=4.84; p=0.028). Adverse outcomes included multiple pregnancies in 15.9% of IVF vs. 6% of IUI cases. Higher success was noted in women aged <30 (IVF: 52.3%; IUI: 39.2%). Anti-Müllerian hormone (AMH) and follicle-stimulating hormone (FSH) were significantly correlated with pregnancy outcomes (AMH: r=0.38 and p<0.001; FSH: r=-0.25 and p=0.011). Logistic regression identified IVF (OR=1.68), AMH (OR=1.52), and FSH (OR=0.81) as significant predictors. A random forest model achieved 73.1% accuracy.

Conclusions

IVF demonstrated superior clinical outcomes over IUI. Hormonal profiling and early IVF consideration may improve ART success in selected infertile patients.