# Four Simultaneous Opportunistic Infections in a Man With Newly Diagnosed HIV

**Authors:** Kai Yoshinaga, Saipriya Ayyar, Adam Sanderson, Hari Polenakovik

PMC · DOI: 10.7759/cureus.92629 · Cureus · 2025-09-18

## TL;DR

A 38-year-old man with newly diagnosed HIV had four opportunistic infections at the same time, highlighting the importance of early HIV detection and treatment.

## Contribution

The case highlights the rare occurrence of multiple opportunistic infections at HIV diagnosis despite improved screening and treatment.

## Key findings

- The patient presented with four simultaneous opportunistic infections upon HIV diagnosis.
- Early HIV detection and treatment are critical to prevent such severe complications.
- This case underscores the need for comprehensive evaluation in newly diagnosed HIV patients.

## Abstract

Human immunodeficiency virus (HIV) directly inhibits the function of the immune system via its anti-CD4 T cell activity, and much of the morbidity associated with HIV is secondary to the effects of opportunistic infections. Advancements in both efficacy and accessibility of HIV screening and therapies have led to patients being managed earlier in their disease courses. This is the case of a 38-year-old male who initially presented with chest pain and was diagnosed with HIV in the setting of four simultaneous opportunistic infections.

## Full-text entities

- **Genes:** CD4 (CD4 molecule) [NCBI Gene 920] {aka CD4mut, IMD79, Leu-3, OKT4D, T4}
- **Diseases:** chest pain (MESH:D002637), Opportunistic Infections (MESH:D009894)
- **Species:** Human immunodeficiency virus (species) [taxon 12721], Human immunodeficiency virus 1 (no rank) [taxon 11676], Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12535253/full.md

## References

14 references — full list in the complete paper: https://tomesphere.com/paper/PMC12535253/full.md

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Source: https://tomesphere.com/paper/PMC12535253