# Revenue Differences Between Top-Selling Small-Molecule Drugs and Biologics in Medicare

**Authors:** Matthew Vogel, William B. Feldman, Zander Cowan, Benjamin N. Rome, Amitabh Chandra, Aaron S. Kesselheim, Olivier J. Wouters

PMC · DOI: 10.1001/jamahealthforum.2025.4720 · JAMA Health Forum · 2025-10-17

## TL;DR

This study compares how much money drug makers made from top-selling small-molecule drugs and biologics in Medicare over 9 to 13 years after FDA approval.

## Contribution

It provides a revenue comparison of drug types eligible for Medicare price negotiations over an extended post-approval period.

## Key findings

- Revenues were analyzed for 9 to 13 years after FDA approval for eligible drugs.
- The study covers negotiation-eligible products approved between 2012 and 2022.
- It highlights differences in revenue generation between small-molecule drugs and biologics.

## Abstract

This study compares the revenues earned by manufacturers 9 vs 13 years following US Food and Drug Administration approval for negotiation-eligible products from 2012 to 2022.

## Full-text entities

- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12534848/full.md

## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12534848/full.md

## References

5 references — full list in the complete paper: https://tomesphere.com/paper/PMC12534848/full.md

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Source: https://tomesphere.com/paper/PMC12534848