Expression of Concern for Ethyl Acetate Extract of Licorice Root (Glycyrrhiza glabra) Enhances Proliferation and Osteogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells [Iran J Pharm Res.17(3):e124804]
Editor-in-Chief IJPR

Abstract
Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.
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Taxonomy
TopicsPharmacological Effects of Natural Compounds · Plant-based Medicinal Research · Natural Compounds in Disease Treatment
The Editors of the Iranian Journal of Pharmaceutical Research (IJPR) have been made aware of concerns regarding the integrity of certain images presented in the article Ethyl Acetate Extract of Licorice Root Enhances Proliferation and Osteogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells (1). Comments posted on the post-publication peer review platform PubPeer have highlighted potential image duplication or overlap between figures in this article and figures published in other unrelated publications. The concerns include similarities between:
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Paper 1: Molecular Biology Reports (2024), Figure 2D (PMID 38270663) (2)
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Paper 2: Cell Journal (2016), Figure 2A (PMID 27540522) (3)
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Paper 3: International Journal of Organ Transplantation Medicine (2014), Figure 4B (PMID 25013621) (4)
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Paper 4: Iranian Journal of Pharmaceutical Research (2018), Figure 3C (PMID 30127828) (1)
Additionally, a separate PubPeer comment suggests that Figure 3B in this article appears to be identical or highly similar to Figure 3B in another publication by Soleimani et al. (2012) (5).
Given these concerns, the editorial office has initiated an investigation in accordance with the journal’s ethical guidelines and COPE recommendations. While this process is ongoing, readers are advised to interpret the findings of this article with caution (1).
We will provide an update once the investigation has concluded and further information becomes available.
Editorial Office
Iranian Journal of Pharmaceutical Research (IJPR)
Date: 1 Aug 2025
The reference list from the paper itself. Each links out to its DOI / PubMed record.
- 1Azizsoltani A Piri K Behzad S Soleimani M Nekouei M Mahmoudi Zet al.Ethyl Acetate Extract of Licorice Root (Glycyrrhiza glabra) Enhances Proliferation and Osteogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells.Iran J Pharm Res.201717330127828 PMC 6094414 · pubmed ↗
- 2Soleimani A Oraee Yazdani S Pedram M Saadinam F Rasaee MJ Soleimani M Intrathecal injection of human placental mesenchymal stem cells derived exosomes significantly improves functional recovery in spinal cord injured rats.Mol Biol Rep.202451110.1007/s 11033-023-08972-738270663 · doi ↗ · pubmed ↗
- 3Allameh A Jazayeri M Adelipour M In Vivo Vascularization of Endothelial Cells Derived from Bone Marrow Mesenchymal Stem Cells in SCID Mouse Model.Cell J.20161821798810.22074/cellj.2016.431227540522 PMC 4988416 · doi ↗ · pubmed ↗
- 4Ayatollahi M Geramizadeh B Zakerinia M Ramzi M Yaghobi R Hadadi Pet al.Human Bone Marrow-derived Mesenchymal Stem Cell: A Source for Cell-Based Therapy.Int J Organ Transplant Med.201231324125013621 PMC 4089277 · pubmed ↗
- 5Pub Peer Discussion of duplicated figure from Soleimani et al., 2012.2025 Available from: https://pubpeer.com/publications/32153 F 120F 9C 7740 DD 2DACD 6B 5EF 56Pub Peer
