# The Acceptance, Commitment and COgnitive RemeDiation (ACCORD) Study: Can a Brief Online Cognitive Intervention Improve Outcomes in Patients With Esophageal Disease?

## TL;DR

A brief online therapy called ACCORD improved mental flexibility and quality of life in patients with esophageal diseases.

## Contribution

ACCORD is a novel telemedicine-based brain-gut behavioral therapy targeting cognitive and psychological inflexibility in esophageal disease patients.

## Key findings

- 89.9% of participants completed the ACCORD intervention, indicating high feasibility and acceptability.
- Participants showed strong reductions in symptom anxiety and improvements in health-related quality of life.
- Moderate to decisive gains in cognitive and psychological flexibility were observed.

## Abstract

Cognitive and psychological inflexibility are two mental processes that influence how a person interprets and responds to esophageal symptoms. Patients with greater mental inflexibility are at risk for poorer outcomes. Brain–gut behavioral therapies (BGBT) are effective adjunctive treatments in many digestive diseases, with potential to improve mental flexibility. We piloted a brief intervention targeting cognitive and psychological inflexibility in patients with esophageal disease. Secondary aims included improving symptoms, mood, and quality of life (QoL) and reducing hypervigilance and symptom anxiety.

Eighty adults newly diagnosed with achalasia, eosinophilic esophagitis, gastroesophageal reflux, or functional dysphagia from an esophageal clinic participated in a non‐randomized, open‐label trial. Acceptance, Commitment and COgnitive RemeDiation (ACCORD) was a novel 4‐week BGBT administered via telemedicine. Feasibility and acceptability were assessed. Evaluations of esophageal symptom severity, cognitive and psychological flexibility, hypervigilance, symptom anxiety, and QoL occurred at baseline and posttreatment. Last observation carried forward was used for patients with incomplete 6‐month data. Bayes Factor evaluated strength of support for study hypotheses.

89.9% of participants completed ACCORD. Moderate to decisive gains occurred for some markers of cognitive flexibility and psychological flexibility, which may demonstrate a delayed but strong improvement. Participants demonstrated strong to decisive reductions in symptoms, symptom anxiety, and decisive increases in health‐related quality of life (HRQoL).

A novel, four‐session BGBT targeting cognitive and psychological flexibility in patients with esophageal disease was feasible, acceptable, and shows potential to improve symptom severity, symptom anxiety, and HRQoL. ACCORD's use of telemedicine may mitigate access issues related to BGBTs. Further study is warranted.

The ACCORD study was a brief telemedicine intervention targeting cognitive and psychological inflexibility in patients with esophageal conditions. ACCORD was feasible and acceptable to patients and demonstrated some improvements in both forms of inflexibility, as well as reductions in certain esophageal symptoms, symptom‐related anxiety, and health‐related quality of life.